The TROPESS CrIS-SNPP L2 for Karachi Megacity, Summary Product contains the vertical distribution of six retrieved atmospheric gases (CH4, CO, HDO, NH3, O3 and PAN), along with formal uncertainties measured by the CrIS instrument on the Suomi-NPP satellite. This summary product is one of the TROPESS Special Collections, centered on a 2x2 degree region over Karachi for the time period from 2016-01-02 to 2021-05-21. The NASA TRopospheric Ozone and Precursors from Earth System Sounding (TROPESS) project, uses an optimal estimation algorithm, known as the MUlti-SpEctra, MUlti-SpEcies, Multi-SEnsors (MUSES).The data files are written in the netCDF version 4 file format, and each file contains one day of data. The data have a spatial resolution of 14 km (CrIS nadir FOV), and are reported at 17 vertical levels from the surface to 0.1 hPa. The principal investigator for the TROPESS project is Kevin W. Bowman.