This dataset contains atmospheric sounding measurements taken during the Sub-Mesoscale Ocean Dynamics Experiment (S-MODE) field campaign. The experiment was conducted approximately 300 km offshore of San Francisco, during a pilot campaign that spanned two weeks in October 2021, and two intensive operating periods in Fall 2022 and Spring 2023. S-MODE aims to understand how ocean dynamics acting on short spatial scales influence the vertical exchange of physical and biological variables in the ocean. Sounding profiles were collected using shipboard Windsond S1H3-S radiosondes launched from the R/V Oceanus cruise OC2108A, to a maximum elevation of at least 5 km above ground level (ABL). These measurements are used to understand the vertical structure of atmospheric temperature, winds, and moisture. The original 1Hz observations were gridded onto a uniform 20 m vertical grid. The data are available in netCDF format with dimensions of altitude and profile number.