The Radiosonde CPEX-CV dataset was collected during the Convective Processes Experiment – Cabo Verde (CPEX-CV) field campaign. The NASA CPEX-CV field campaign was based out of Sal Island, Cabo Verde from August through September 2022. The campaign is a continuation of CPEX – Aerosols and Winds (CPEX-AW) and was conducted aboard the NASA DC-8 aircraft equipped with remote sensors and dropsonde-launch capability that will allow for the measurement of tropospheric aerosols, winds, temperature, water vapor, and precipitation. The overarching CPEX-CV goal was to investigate atmospheric dynamics, marine boundary layer properties, convection, the dust-laden Saharan Air Layer, and their interactions across various spatial scales to improve understanding and predictability of process-level lifecycles in the data-sparse tropical East Atlantic region. These radiosonde data files include wind direction, dew point temperature, geopotential height, mixing ratio, atmospheric pressure, relative humidity, wind speed, temperature, potential temperature, equivalent potential temperature, and virtual potential temperature measurements at various levels of the troposphere. These data files are available from September 1, 2022, through September 29, 2022 in netCDF-4 format.