A study of alterations in DNA epigenetic modifications (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells

Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type

Data and Resources

Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 20:08 (UTC)
Created February 19, 2025, 06:44 (UTC)
accessLevel public
accrualPeriodicity irregular
bureauCode {026:00}
catalog_@context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
catalog_@id https://data.nasa.gov/data.json
catalog_conformsTo https://project-open-data.cio.gov/v1.1/schema
catalog_describedBy https://project-open-data.cio.gov/v1.1/schema/catalog.json
harvest_object_id 74648ece-1321-461c-b2e2-a491791461fe
harvest_source_id b37e5849-07d2-41cd-8bb6-c6e83fc98f2d
harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-86_hdmh-sact
issued 2018-06-26
landingPage https://data.nasa.gov/dataset/a-study-of-alterations-in-dna-epigenetic-modifications-5mc-and-5hmc-influenced-by-simulate
modified 2023-01-26
programCode {026:005}
publisher National Aeronautics and Space Administration
resource-type Dataset
source_datajson_identifier true
source_hash f1bbe19164bbd789758a036aa74e57cf29631b776524bcd6585b8437913eb493
source_schema_version 1.1
theme {"Earth Science"}