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Proton irradiation augments the reduction in tumor progression observed with...
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that in... -
Microarray Analysis of Space-flown Murine Thymus Tissue
Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to detail the gene... -
The Arabidopsis spaceflight transcriptome: a comparison of whole plants to...
Arabidopsis thaliana was evaluated for its response to the spaceflight environment in three replicated experiments on the International Space Station. Two approaches were used;... -
The influence of simulated microgravity on the proteome of Daphnia magna
Background/Objectives: The waterflea Daphnia is an interesting candidate for bioregenerative life support systems (BLSS). These animals are particularly promising because of... -
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland...
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources... -
Hindlimb suspension and reloading study
Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice 14 days -Hindlimb suspension for 7 days... -
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under...
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls. Cells were... -
Rodent Research-3-CASIS: Mouse adrenal gland transcriptomic proteomic and...
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
BRIC-23 GeneLab Process Verification Test: Bacillus subtilis transcriptomic...
Microbes interact with humans in complex ways and understanding how they respond to the spaceflight environment is important to the success of future manned spaceflight... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse kidney transcriptomic...
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources... -
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic...
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver... -
Chronic low dose-rate versus acute ionizing radiation induced gene...
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast... -
A whole-genome microarray study of Arabidopsis thaliana cell cultures...
Arabidopsis thaliana wild type cell cultures were exposed to a 5-day space flight onboard of Shenzhou 8 to identify microgravity and space effect related gene expression. -
BASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight R. rubrum cultures returned back to Earth. These... -
Microgravity effect on C. elegans N2/VC (CERISE 4 days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese Module of the... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Gene expression profiling of C. elegans under various thermal conditions
To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The... -
Genechip analysis of bone marrow osteoprogenitors exposed to microgravity
In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their... -
Transcription profiling of rat response to changes in developmental stage -...
Transcriptional crosstalk between mammary gland liver and adipose tissue Experiment Overall Design: Pregnant and Lactating rats exposed to 3 gravity conditions