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Transcription profiling of atm mutant adm mutant and wild type whole plants...
Whole seedlings of wild type (4d) and atm mutants (4d) have been analyzed after a gamma ray irradiation of 0.75h 1.5h 3h & 5h (time course). Roots of wt (4d) atm (3d) and... -
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model...
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus... -
Exposure to ionizing radiation induced persistent gene expression changes in...
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body xce xb3 radiation and mammary glands were surgically removed 2-month after radiation. RNA was... -
Low dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 cGy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 cGy RNA is isolated and labeled using a T7 amplification... -
Transcriptomic analysis of spleens from mice subjected to chronic low-dose...
The purpose of this study was to evaluate transcriptional changes in mouse spleens using a ground-based model for spaceflight. This model includes prolonged unloading and low-... -
miRNA signature detection and countermeasures against HZE radiation exposure...
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA work has... -
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU)...
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose radiation. Low-... -
Gene expression profiles of irradiated lung tissue in three mouse strains
The aim of our research is to clarify the mechanisms generating heterogeneity in response to C-ion irradiation that arise from individual genetic variations in humans. In this... -
miRNA signature detection and countermeasures against HZE radiation exposure...
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA work has... -
Gene expression data from 4T1 irradiated tumors treated with TGFbeta blockade
Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ individualized vaccine; however this potential... -
Chronic low dose-rate versus acute ionizing radiation induced gene...
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
miRNA signature detection and countermeasures against HZE radiation exposure...
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA work has... -
Radiation responses in peripheral white blood cells of smokers and non-smokers
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not been fully... -
Gene expression in blood of mice with internal exposure to Cs-137
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled it can expose the entire body for an extended period... -
Radiation-induced bystander effects and gene expression in cells deficient for RAD9
Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation... -
IMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect in which non-irradiated cells respond to signals from irradiated cells is well established. It raises concerns for the... -
IMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the... -
Global DNA methylation profiling of radiation-induced rat mammary carcinomas
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat mammary... -
Identification of miRNAs involved in cell response to ionising radiation and...
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation....