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Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model...
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus... -
Low dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 cGy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 cGy RNA is isolated and labeled using a T7 amplification... -
MESSAGE 2 space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid agar rich media was sent to the ISS in October 2003 (MESSAGE-part 2 experiment). After 10 days flight R. rubrum cultures returned back to... -
Radiation responses in peripheral white blood cells of smokers and non-smokers
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not been fully... -
Gene responses in mouse brain to long-term exposure to microgravity
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed on the... -
T Cell Activation in Microgravity Compared to 1g (Earth s) Gravity
This study tested the hypothesis that transcription of immediate early genes is inhibited in T cells activated in microgravity (uG). Immunosuppression during spaceflight is a... -
An environment with strong gravitational and magnetic field alterations...
Using diamagnetic levitation we have exposed A. thaliana in vitro callus cultures to five environments with different levels of effective gravity (from levitation i.e. simulated... -
Microarray Profile of Gene Expression during Osteoclast Differentiation in...
Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA developed... -
Microgravity effect on C. elegans N2/VC (CERISE 8days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 8 days in the Japanese Module of the... -
BASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight R. rubrum cultures returned back to Earth. These... -
IMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect in which non-irradiated cells respond to signals from irradiated cells is well established. It raises concerns for the... -
IMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the... -
Bacillus subtilis spores PROTECT experiment Space-exposed and Mars-exposed...
Because of their ubiquity and resistance to spacecraft decontamination bacterial spores are considered likely potential forward contaminants on robotic missions to Mars. Thus it... -
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity
Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety health and performance of the crewmembers. As a... -
DNA copy number analysis from mice with radiation-induced acute myeloid leukemia
Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using spleen DNA... -
Expression data from SPHINX (SPaceflight of Huvec: an INtegrated eXperiment)
Changes in the physical environment modulate cell responses and may lead to the impairment or even failure of tissue function as a result of mechanotransduction processes. It... -
Genechip analysis of bone marrow osteoprogenitors exposed to microgravity
In March 2006 murine Bone Marrow Stromal Cells (BMSC) were flown in the Soyuz 12S to the International Space Station to investigate the effects of microgravity on their... -
Salmonella Typhimurium transcription profiles in space flight
Salmonella transcription profiles were obtained from samples flown on space shuttle mission STS-115 and compared to profiles from Salmonella grown under identical conditions on... -
Woman skeletal muscle transcriptome with bed rest and countermeasures.
Microgravity has a dramatic impact on human physiology illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of... -
Gene expression profiling of C. elegans under various thermal conditions
To realistically evaluate the effects of the environment in space it is necessary to understand the effects of external factors during sample transport from Earth to space. The...