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Identifying radiation exposure biomarkers from mouse blood transcriptome
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological samples... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Gene expression in human peripheral blood 48 hours after exposure to...
Analysis of human peripheral blood 48 hours after irradiation ex vivo with graded doses of gamma rays. Results have been used in building and testing classifiers to predict... -
Expression profiling of murine lung 70 days following exposure to...
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or... -
Gene expression data from 4T1 irradiated tumors treated with TGFbeta blockade
Accumulating data support the concept that ionizing radiation therapy (RT) has the potential to convert the tumor into an in situ individualized vaccine; however this potential... -
Low dose ionizing radiation treated lymphoblastoid cells
Irradiated cell lines exposed to 1-10 Gy 2 Lymphoblastoid cell lines (GM15510 and GM15036) irradiated 1 2.5 5 7.5 10 Gy RNA is isolated and labeled using a T7 amplification... -
Comparison of gene expression profiles of normal human bronchial epithelial...
The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial... -
Identification of miRNAs involved in cell response to ionising radiation and...
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation.... -
DNA copy number analysis from mice with radiation-induced acute myeloid leukemia
Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using spleen DNA... -
Radiation responses in peripheral white blood cells of smokers and non-smokers
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not been fully... -
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model...
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus... -
Gene expression in blood of mice with internal exposure to Cs-137
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled it can expose the entire body for an extended period... -
Gene expression profiling of PBL in response to ionising radiation and...
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation.... -
Non-targeted effects of low dose ionizing radiation act via TGF-beta to...
This is a genome-wide approach to identifying genes persistently induced in the mouse mammary gland by acute whole body low dose ionizing radiation (10cGy) 1 and 4 weeks after... -
Gene expression profiles of irradiated lung tissue in three mouse strains
The aim of our research is to clarify the mechanisms generating heterogeneity in response to C-ion irradiation that arise from individual genetic variations in humans. In this... -
Exposure to ionizing radiation induced persistent gene expression changes in...
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body xce xb3 radiation and mammary glands were surgically removed 2-month after radiation. RNA was...